Cdh23^tm1.1Ugds
Targeted Allele Detail

Summary

• Symbol: Cdh23^tm1.1Ugds
• Name: cadherin related 23 (otocadherin); targeted mutation 1.1, Unite de Genetique des Deficits Sensoriels
• MGI ID: MGI:4361286
• Synonyms: Cdh23^fl
• Gene: Cdh23 Location: Chr10:60138527-60532269 bp, - strand Genetic Position: Chr10, 30.11 cM
• Alliance: Cdh23^tm1.1Ugds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158897
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 62 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 68. Flp mediated recombination removed the neo cassette leaving exons 62 through 68 floxed. (J:158897)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh23 Mutation: 280 strains or lines available

References

• Original: J:158897 Etournay R, et al., Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape. Development. 2010 Apr;137(8):1373-83
• All: 2 reference(s)