Mirc32^tm1.2Eno
Targeted Allele Detail

Summary

• Symbol: Mirc32^tm1.2Eno
• Name: microRNA cluster 32, including Mir143 and Mir145a; targeted mutation 1.2, Eric N Olson
• MGI ID: MGI:4359265
• Synonyms: Mir145/Mir143^tm1.2Eno
• Gene: Mirc32 Location: Chr18:61780896-61782329 bp Genetic Position: Chr18, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152458
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A loxP site was inserted upstream of Mir143 and an frt-flanked neo cassette with a downstream loxP site was inserted downstream of Mir145. Flp-mediated recombination followed by cre-mediated recombination or cre-mediated recombination alone removed the selection cassette, Mir143, and Mir145. (J:152458)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc32 Mutation: 3 strains or lines available

References

• Original: J:152458 Xin M, et al., MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev. 2009 Sep 15;23(18):2166-78
• All: 1 reference(s)