Rev1^tm1.1Jow
Targeted Allele Detail

Summary

• Symbol: Rev1^tm1.1Jow
• Name: REV1, DNA directed polymerase; targeted mutation 1.1, Jiyang O-Wang
• MGI ID: MGI:4355740
• Synonyms: REV1AA
• Gene: Rev1 Location: Chr1:38091867-38168882 bp, - strand Genetic Position: Chr1, 16.46 cM, cytoband B
• Alliance: Rev1^tm1.1Jow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151700
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 10 was replaced with one in which alanines replaced highly conserved aspartate and glutamate residues at positions 568 and 569. A floxed neo cassette was inserted downstream of the modified exon 10 and removed by germ line, cre mediated recombination. (J:151700)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rev1 Mutation: 68 strains or lines available

References

• Original: J:151700 Masuda K, et al., A critical role for REV1 in regulating the induction of C:G transitions and A:T mutations during Ig gene hypermutation. J Immunol. 2009 Aug 1;183(3):1846-50
• All: 2 reference(s)