Tmem41b^{Gt(OST208407)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Tmem41b^{Gt(OST208407)Lex}
• Name: transmembrane protein 41B; gene trap OST208407, Lexicon Genetics
• MGI ID: MGI:4232785
• Synonyms: Stas -
• Gene: Tmem41b Location: Chr7:109571394-109586136 bp, - strand Genetic Position: Chr7, 57.69 cM
• Alliance: Tmem41b^{Gt(OST208407)Lex} page

Mutation origin

• Mutant Cell Line: OST208407
• Germline Transmission: Earliest citation of germline transmission: J:272518
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A lentiviral gene trap vector inserted into the first intron of the Tmem41b (Stasimon) gene. RT-qPCR analysis revealed a ~50% reduction of mRNA levels in heterozygous mutant embryos and the absence of mRNA expression in homozygous mutant embryos at E8.5.
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST208407	CG575003 ; (MGI Seq Detail)	3' RACE	Chr7:109575873-109581978 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  11 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tmem41b Mutation: 18 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 3 reference(s)