Rag1^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Rag1^m1Btlr
• Name: recombination activating 1; mutation 1, Bruce Beutler
• MGI ID: MGI:3851764
• Synonyms: maladaptive, Rag1^maladaptive
• Gene: Rag1 Location: Chr2:101468627-101479846 bp, - strand Genetic Position: Chr2, 53.88 cM
• Alliance: Rag1^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was identified in a blood screen of G3 progeny of an ENU mutagenized male mouse. The mutation comprises a C to A transversion at nucleotide position 2783 of the gene. It converts the codon encoding tyrosine at amino acid position 886, in the C-terminal region of the core protein sequence, to a translation termination codon (Y886Ter). This is predicted to truncate the core by 123 and the full length protein by 155 amino acids. (J:150635)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rag1 Mutation: 120 strains or lines available

References

• Original: J:150635 Siggs OM, et al., Record for B9712, updated July 2009. Accessed 21 July 2009. MGI Direct Data Submission. 2009
• All: 5 reference(s)