Grid2^tm2Msmh
Targeted Allele Detail

Summary

• Symbol: Grid2^tm2Msmh
• Name: glutamate receptor, ionotropic, delta 2; targeted mutation 2, Masayoshi Mishina
• MGI ID: MGI:3851243
• Synonyms: GluRdelta2^deltaS
• Gene: Grid2 Location: Chr6:63232860-64681307 bp, + strand Genetic Position: Chr6, 29.77 cM
• Alliance: Grid2^tm2Msmh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150621
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The Shank-binding segment in exon 16 was removed and an frt-flanked neo cassette was inserted downstream of the modified exon. Reduced protein expression was confirmed by western blot analysis on cerebellar extracts. (J:150621)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grid2 Mutation: 87 strains or lines available

References

• Original: J:150621 Yasumura M, et al., Role of the internal Shank-binding segment of glutamate receptor delta2 in synaptic localization and cerebellar functions. Neurosci Lett. 2008 Mar 12;433(2):146-51
• All: 1 reference(s)