Gpsm2^{tm1.1(Venus)Fuma}
Targeted Allele Detail

Summary

• Symbol: Gpsm2^{tm1.1(Venus)Fuma}
• Name: G-protein signalling modulator 2 (AGS3-like, C. elegans); targeted mutation 1.1, Fumio Matsuzaki
• MGI ID: MGI:3850859
• Synonyms: Gpsm2^{tm1.1(YFP)Fuma}, LGN-VenusC
• Gene: Gpsm2 Location: Chr3:108585954-108629625 bp, - strand Genetic Position: Chr3, 47.53 cM, cytoband F3
• Alliance: Gpsm2^{tm1.1(Venus)Fuma} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132370
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A loxP site and an frt flanked pGKNeo cassette were inserted upstream of exon 13. A modified YFP reporter (Venus) was inserted in frame in exon 15. Mice expressing the fusion protein encoded by this modification were crossed with an unspecified FLP expressing mouse line to excise the neomycin selection cassette. The resulting allele has exons 13 through the coding portion of exon 15 flanked by loxP sites. (J:132370)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gpsm2 Mutation: 26 strains or lines available

References

• Original: J:132370 Konno D, et al., Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis. Nat Cell Biol. 2008 Jan;10(1):93-101
• All: 1 reference(s)