Pds5b^{Tg(Wap-ERBB2)229Wzw}
Transgenic Allele Detail

Summary

• Symbol: Pds5b^{Tg(Wap-ERBB2)229Wzw}
• Name: PDS5 cohesin associated factor B; transgene insertion 229, Wei-Zen Wei
• MGI ID: MGI:3850477
• Synonyms: Her-2 Tg, Tg(Wap-ERBB2)229Wzw, WAP-Her-2
• Gene: Pds5b Location: Chr5:150597204-150734155 bp, + strand Genetic Position: Chr5, 89.61 cM
• Alliance: Pds5b^{Tg(Wap-ERBB2)229Wzw} page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Pds5b^{Tg(Wap-ERBB2)229Wzw} expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ERBB2 (2064)

  Erbb2

  (MGI:95410)

• Mutation details: A transgenic construct containing a mouse 2.6 kb whey acidic protein (Wap) promoter fused to a human ERBB2 4.4 kb cDNA followed by the bovine growth hormone polyadenylation signal. Line 229 inserted into intron 2 (19 bp upstream of exon 3). (J:132829, J:233887)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pds5b Mutation: 100 strains or lines available

References

• Original: J:132829 Piechocki MP, et al., Human ErbB-2 (Her-2) transgenic mice: a model system for testing Her-2 based vaccines. J Immunol. 2003 Dec 1;171(11):5787-94
• All: 11 reference(s)