Srsf10^tm1Jalm
Targeted Allele Detail

Summary

• Symbol: Srsf10^tm1Jalm
• Name: serine and arginine-rich splicing factor 10; targeted mutation 1, James L Manley
• MGI ID: MGI:3848950
• Synonyms: SRp38^-
• Gene: Srsf10 Location: Chr4:135583058-135597219 bp, + strand Genetic Position: Chr4, 68.01 cM, cytoband D3
• Alliance: Srsf10^tm1Jalm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149480
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on ventricle extracts. (J:149480)

Expression

In Mice Carrying this Mutation:	38 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srsf10 Mutation: 29 strains or lines available

References

• Original: J:149480 Feng Y, et al., SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart. Dev Cell. 2009 Apr;16(4):528-38
• All: 3 reference(s)