Fermt2^{Gt(AM0293)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Fermt2^{Gt(AM0293)Wtsi}
• Name: fermitin family member 2; gene trap AM0293, Wellcome Trust Sanger Institute
• MGI ID: MGI:3845885
• Synonyms: kindlin-2^-
• Gene: Fermt2 Location: Chr14:45696252-45767575 bp, - strand Genetic Position: Chr14, 22.97 cM
• Alliance: Fermt2^{Gt(AM0293)Wtsi} page

Mutation origin

• Mutant Cell Line: AM0293
• Germline Transmission: Earliest citation of germline transmission: J:147662
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0lxr
• Mutation details: A gene trap vector containing promoterless beta-geo is inserted between exons 11 and 12 of the gene in the middle of the FERM domain and creates a premature stop codon. (J:147662)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  AM0293	CL569406 ; (MGI Seq Detail)	5' RACE	Chr14:45702180-45702261 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  73 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fermt2 Mutation: 32 strains or lines available

References

• Original: J:147662 Dowling JJ, et al., Kindlin-2 is an essential component of intercalated discs and is required for vertebrate cardiac structure and function. Circ Res. 2008 Feb 29;102(4):423-31
• All: 3 reference(s)