Mmp28^tm1Mani
Targeted Allele Detail

Summary

• Symbol: Mmp28^tm1Mani
• Name: matrix metallopeptidase 28 (epilysin); targeted mutation 1, Anne M Manicone
• MGI ID: MGI:3836773
• Synonyms: Epilysin^-
• Gene: Mmp28 Location: Chr11:83331594-83353890 bp, - strand Genetic Position: Chr11, 50.39 cM
• Alliance: Mmp28^tm1Mani page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145912
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4-7 and the coding portion of exon 8 were replaced with a neomycin selection cassette. This mutation was predicted to be a null allele because the remaining exons 1-3 only encode the proregion of the protein product. Protein product was absent in the airways of homozygote mice as determined by immunofluorescence staining. (J:145912)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mmp28 Mutation: 28 strains or lines available

References

• Original: J:145912 Manicone AM, et al., Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia. J Immunol. 2009 Mar 15;182(6):3866-76
• All: 4 reference(s)