Lck^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Lck^m1Btlr
• Name: lymphocyte protein tyrosine kinase; mutation 1, Bruce Beutler
• MGI ID: MGI:3831661
• Synonyms: iconoclast
• Gene: Lck Location: Chr4:129442142-129467415 bp, - strand Genetic Position: Chr4, 63.26 cM, cytoband distal
• Alliance: Lck^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was discovered in an in vivo screen of G3 progeny of an ENU mutagenized male mouse for natural killer cell and CD8⁺ cytotoxicity. It comprises a T to C transition at nucleotide position 1086 (Genbank Accession NM_010693), in the eighth of the gene's 12 exons, resulting in replacement of leucine by proline at amino acid position 300 of the protein (L300P). (J:144695)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lck Mutation: 93 strains or lines available

References

• Original: J:144695 Krebs P, et al., Record for "iconoclast", updated 3 Feb 2009. MGI Direct Data Submission. 2009
• All: 1 reference(s)