Sox9^tm2Gsr
Targeted Allele Detail

Summary

• Symbol: Sox9^tm2Gsr
• Name: SRY (sex determining region Y)-box 9; targeted mutation 2, Gerd Scherer
• MGI ID: MGI:3817218
• Synonyms: Sox9^neo, Sox9-neoflox
• Gene: Sox9 Location: Chr11:112673050-112678586 bp, + strand Genetic Position: Chr11, 77.27 cM
• Alliance: Sox9^tm2Gsr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141017
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: This allele contains a loxP-flanked neomycin resistance (neo) cassette inserted into intron 1 and a third loxP site downstream of exon 3. Presence of the neo cassette leads to aberrant splicing and decreased expression levels, making this allele hypomorphic. Cre recombinase excision of only the neo cassette produces Sox9^tm1Gsr; excision of both the neo cassette and the floxed segment containing exons 2 and 3 yields Sox9^tm1.1Gsr. (J:75124, J:141017)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sox9 Mutation: 32 strains or lines available

References

• Original: J:75124 Kist R, et al., Conditional inactivation of Sox9: a mouse model for campomelic dysplasia. Genesis. 2002 Feb;32(2):121-3
• All: 2 reference(s)