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Targeted Allele Detail
Symbol: Sox9tm1.1Gsr
Name: SRY (sex determining region Y)-box 9; targeted mutation 1.1, Gerd Scherer
MGI ID: MGI:2385469
Synonyms: Sox9-delex2,3
Gene: Sox9  Location: Chr11:112673050-112678586 bp, + strand  Genetic Position: Chr11, 77.27 cM
Germline Transmission:  Earliest citation of germline transmission: J:75124
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis allele lacks exons 2 and 3, which encode a portion of the DNA-binding high mobility group domain and the entire transactivation domain. It can be derived from Sox9tm1Gsr by cre recombinase excision of the loxP-flanked region containing exons 2 and 3 or from Sox9tm2Gsr by simultaneous excision of exons 2 and 3 and of a loxP-flanked neo cassette (which has been deleted in Sox9tm1Gsr). (J:75124)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox9 Mutation:  16 strains or lines available
Original:  J:75124 Kist R, et al., Conditional inactivation of Sox9: a mouse model for campomelic dysplasia. Genesis. 2002 Feb;32(2):121-3
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory