Tg(Igk*C)C06Dgs
Transgene Detail

Summary

• Symbol: Tg(Igk*C)C06Dgs
• Name: transgene insertion C06, David G Schatz
• MGI ID: MGI:3811483
• Synonyms: TgC
• Transgene: Tg(Igk*C)C06Dgs Location: unknown
• Alliance: Tg(Igk*C)C06Dgs page

Transgene origin

• Strain of Origin: C57BL/6 and SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igk*C)C06Dgs expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Igk (MGI:96494)

• Mutation details: Vk167/PEPS is an Igk transgene with a truncated region upstream of the promoter. The Igk (immunoglobulin kappa) sequence was further modified through the insertion, near the 3' end of the variable region of Igk, of 5 tandem repeats of a 20-bp adenine/thymine (A/T) fragment which is in the same orientation as the insert in the TgT line but also includes a single guanine:cytosine (G:C) base pair in the central repeat. In this "TgC" line, the cytosine was placed on the 5'->3' strand of the DNA. (J:139793)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:139793 Unniraman S, et al., Strand-biased spreading of mutations during somatic hypermutation. Science. 2007 Aug 31;317(5842):1227-30
• All: 1 reference(s)