Tg(TACSTD1)02Leij
Transgene Detail

Summary

• Symbol: Tg(TACSTD1)02Leij
• Name: transgene insertion 02, Prof Lou de Leij
• MGI ID: MGI:3802950
• Synonyms: BACF2, EGP-2 tg, hEpCAM Tg, Hu-EpCAM, TgN(EGP2BAC)2
• Transgene: Tg(TACSTD1)02Leij Location: unknown
• Alliance: Tg(TACSTD1)02Leij page

Transgene origin

• Strain of Origin: FVB/NHsd

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(TACSTD1)02Leij expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EPCAM (4072)

  Epcam

  (MGI:106653)

• Mutation details: A transgenic construct containing the human tumor-associated calcium signal transducer 1 gene (TACSTD1), isolated from a BAC clone, was injected into fertilized FVB/NHsd mouse eggs. Founder line 02 (BACF2) was subsequently established. Transgene expression is directed to the membrane of epithelial cells and is detected in various epithelia in kidney, airways, bile ducts, GI tract (epithelium of villi and crypts of small and large intestine) and in glandular epithelium of reproductive system (epithelium of endometrium, testis tubuli seminifer and epithelium of fallopian ducts), as well as in Hassall's corpuscles in the thymus. Pattern is similar to human expression patterns in normal and tumor tissues. (J:69638)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:69638 McLaughlin PM, et al., The epithelial glycoprotein 2 (EGP-2) promoter-driven epithelial-specific expression of EGP-2 in transgenic mice: a new model to study carcinoma-directed immunotherapy. Cancer Res. 2001 May 15;61(10):4105-11
• All: 4 reference(s)