Cul7^tm1Zqp
Targeted Allele Detail

Summary

• Symbol: Cul7^tm1Zqp
• Name: cullin 7; targeted mutation 1, Zhen-Qiang Pan
• MGI ID: MGI:3801047
• Gene: Cul7 Location: Chr17:46961264-46975290 bp, + strand Genetic Position: Chr17, 22.9 cM
• Alliance: Cul7^tm1Zqp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137062
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced exons 2-4 such that the translation initiation site located in exon 2 was disrupted via homologous recombination. By immunoblot, no protein was detected in MEF isolated from homozygous null embryos. (J:137062)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cul7 Mutation: 70 strains or lines available

References

• Original: J:137062 Xu X, et al., The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. Mol Cell. 2008 May 23;30(4):403-14
• All: 2 reference(s)