Del(5D5Mit348-D5Mit389)6Jcs
Radiation induced Allele Detail

Summary

• Symbol: Del(5D5Mit348-D5Mit389)6Jcs
• Name: deletion, Chr 5, John C. Schimenti 6; deletion, Chr 5, John C Schimenti 6
• MGI ID: MGI:3798176
• Synonyms: Del6Jcs, Dpp6^df1J
• Gene: Del(5D5Mit348-D5Mit389)6Jcs Location: Chr5:25124117-30804638 bp Genetic Position: Chr5, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67077
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Intergenic deletion
• Del(5D5Mit348-D5Mit389)6Jcs involves 97 genes/genome features (Prkag2, 1500035N22Rik, 2900005J15Rik ...) View all
• Mutation details: Targeted insertion of thymidine kinase into the C57BL/6J derived Chromosome 5 Dpp6 locus in the v6.4 ES cell line was followed by 400 Gy of gamma radiation, FIAU selection, and injection into C57BL/6J blastocysts. This deletion includes D5Mit348 through D5Mit389 and falls outside of the Wolf-Hirschhorn syndrome critical region. (J:67077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(5D5Mit348-D5Mit389)6Jcs Mutation: 0 strains or lines available

References

• Original: J:67077 Naf D, et al., Mouse models for the Wolf-Hirschhorn deletion syndrome. Hum Mol Genet. 2001 Jan 15;10(2):91-8
• All: 2 reference(s)