Pde10a^tm1(tTA)Yoko
Targeted Allele Detail

Summary

• Symbol: Pde10a^tm1(tTA)Yoko
• Name: phosphodiesterase 10A; targeted mutation 1, Mineto Yokoi
• MGI ID: MGI:3794648
• Synonyms: PDE10A2^rTA, Pde10a2^tm1(tTA)Yok
• Gene: Pde10a Location: Chr17:8744204-9205480 bp, + strand Genetic Position: Chr17, 4.96 cM
• Alliance: Pde10a^tm1(tTA)Yoko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135447
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Hypomorph, Modified isoform(s))
• Mutation: Insertion
• Mutation details: A tetracycline transactivator (tTA) and a self-excising neo cassette (ACN, in reverse orientation) were inserted into exon 1 immediately downsteam of the initiation methionine. The neo cassette excision occurred within ES cells. Immunohistochemistry confirmed very low levels of protein expression in the brain. This is a hypomorphic allele that targets isoform 2, the main isoform expressed in the brain. (J:135447)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde10a Mutation: 60 strains or lines available

References

• Original: J:135447 Sano H, et al., Increased social interaction in mice deficient of the striatal medium spiny neuron-specific phosphodiesterase 10A2. J Neurochem. 2008 Apr;105(2):546-56
• All: 9 reference(s)