Gata1^tm10Sho
Targeted Allele Detail

Summary

• Symbol: Gata1^tm10Sho
• Name: GATA binding protein 1; targeted mutation 10, Stuart H Orkin
• MGI ID: MGI:3778536
• Synonyms: Gata1^3SA
• Gene: Gata1 Location: ChrX:7825504-7842844 bp, - strand Genetic Position: ChrX, 3.59 cM, cytoband A2
• Alliance: Gata1^tm10Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132560
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed neo cassette was inserted downstream of exon 4 and exon 2, 3 and 6 were replaced with the corresponding exons containing nucleotide substitutions that resulted in amino acid substitutions of alanine for serine at positions 72, 142 and 310 (S72A, S142A and S310A). The neo cassette was removed by germ-line, cre-mediated recombination. (J:132560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata1 Mutation: 44 strains or lines available

References

• Original: J:132560 Rooke HM, et al., Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo. Blood. 2006 May 1;107(9):3527-30
• All: 1 reference(s)