Ptk2^tm1Mmsh
Targeted Allele Detail

Summary

• Symbol: Ptk2^tm1Mmsh
• Name: PTK2 protein tyrosine kinase 2; targeted mutation 1, Masayoshi Mishina
• MGI ID: MGI:3777585
• Synonyms: Fak^flox
• Gene: Ptk2 Location: Chr15:73076951-73295129 bp, - strand Genetic Position: Chr15, 33.94 cM
• Alliance: Ptk2^tm1Mmsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132715
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 15 and an additional loxP site was inserted upstream of exon 15. Germ-line, frt-mediated recombination was used to remove the neo cassette resulting in a floxed exon 15. (J:132715)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptk2 Mutation: 90 strains or lines available

References

• Original: J:132715 Watanabe F, et al., Effects of FAK ablation on cerebellar foliation, Bergmann glia positioning and climbing fiber territory on Purkinje cells. Eur J Neurosci. 2008 Feb;27(4):836-54
• All: 1 reference(s)