Gt(ROSA)26Sor^tm1Uzs
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1Uzs
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ursula Zimber-Strobl
• MGI ID: MGI:3776037
• Synonyms: CD40/LMP1^flSTOP, Gt(ROSA)26Sor^{tm1(CD40/Lmp1)Uzs}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1Uzs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130768
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, No functional change)
• Mutation: Insertion
• Mutation details: cDNA encoding the first 214 amino acids of Cd40 were fused to the cDNA encoding the Epstein-Barr latent membrane protein 1 (LMP1) and inserted into a modified ROSA locus that contained a floxed stop, non-expressing RFP and frt-flanked neo cassette. The fusion protein is only expressed following cre-mediated recombination to remove the stop cassette. (J:130768)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1046 strains or lines available

References

• Original: J:130768 Rastelli J, et al., LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1. Blood. 2008 Feb 1;111(3):1448-55
• All: 1 reference(s)