Ikbkg^tm1Dwb
Targeted Allele Detail

Summary

• Symbol: Ikbkg^tm1Dwb
• Name: inhibitor of kappaB kinase gamma; targeted mutation 1, Dean Ballard
• MGI ID: MGI:3775942
• Synonyms: NEMO-K392R, NEMO-KR
• Gene: Ikbkg Location: ChrX:73436896-73497460 bp, + strand Genetic Position: ChrX, 38.0 cM
• Alliance: Ikbkg^tm1Dwb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136353
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: Gene targeting was used to introduce a single point mutation in the codon for Lys-392, converting it to an arginine. (J:136353)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikbkg Mutation: 15 strains or lines available

References

• Original: J:136353 Ni CY, et al., Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo. J Immunol. 2008 Jun 1;180(11):7107-11
• All: 2 reference(s)