Del(5Cyp3a57-Cyp3a59)2Nki
Targeted Allele Detail

Summary

• Symbol: Del(5Cyp3a57-Cyp3a59)2Nki
• Name: deletion, Chr 5, The Netherlands Cancer Institute 2
• MGI ID: MGI:3775604
• Synonyms: Cyp3a^tm1.1Ahs, Del1Ahs, Del2Nki, Del(5Cyp3a57-Cyp3a59)1Ahs
• Gene: Del(5Cyp3a57-Cyp3a59)2Nki Location: Chr5:145282089-146050097 bp Genetic Position: Chr5, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127366
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Intergenic deletion, Intragenic deletion
• Del(5Cyp3a57-Cyp3a59)2Nki involves 17 genes/genome features (Cyp3a57, Gm2314, Cyp3a16 ...) View all
• Mutation details: The intronic sequence between exon 2 and 3 of Cyp3a57 was replaced with a floxed neo cassette and 2.2 kb downstream of exon 13 a thymidine kinase and a floxed hygromycin cassette were inserted into the genomic sequence of Cyp3a59. Transfection of ES cells with a cre recombinase resulted in the deletion of Cyp3a57, Cyp3a16, Cyp3a41, Cyp3a44, Cyp3a11, Cyp3a25 and Cyp3a59. (J:127366)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(5Cyp3a57-Cyp3a59)2Nki Mutation: 0 strains or lines available

References

• Original: J:127366 van Herwaarden AE, et al., Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. J Clin Invest. 2007 Nov;117(11):3583-92
• All: 3 reference(s)