Tg(Cryaa-Plau)524Lmgd
Transgene Detail

Summary

• Symbol: Tg(Cryaa-Plau)524Lmgd
• Name: transgene insertion 524, Laboratory of Mammalian Genes and Development, Heiner Westphal
• MGI ID: MGI:3769394
• Synonyms: alphaMUPA, alphaMUPA mice, TgN(aMUPA)524West
• Transgene: Tg(Cryaa-Plau)524Lmgd Location: unknown
• Alliance: Tg(Cryaa-Plau)524Lmgd page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cryaa-Plau)524Lmgd expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Plau (MGI:97611)

• Mutation details: This transgene expresses the full-length cDNA encoding the murine urokinase-type plasminogen activator (uPA) from the enhancer-promoter region of the aA-crystallin (Cryaa) gene. Expression of the encoded protein is observed in the ocular lens, and unexpectedly, in retina and brain. (J:111127)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:111127 Miskin R, et al., Human and murine urokinase cDNAs linked to the murine alpha A-crystallin promoter exhibit lens and non-lens expression in transgenic mice. Eur J Biochem. 1990 May 31;190(1):31-8
• All: 24 reference(s)