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Hrktm1Ast
Targeted Allele Detail
Summary
Symbol: Hrktm1Ast
Name: harakiri, BCL2 interacting protein (contains only BH3 domain); targeted mutation 1, Andreas Strasser
MGI ID: MGI:3720713
Synonyms: Hrk-
Gene: Hrk  Location: Chr5:118307829-118327543 bp, + strand  Genetic Position: Chr5, 58.16 cM, cytoband F
Alliance: Hrktm1Ast page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124044
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe single coding exon was replaced with a reporter gene that encodes NLS-betagal with a floxed neo cassette. The neo was subsequently removed via cre mediated recombination. Absence of transcript was confirmed in Northern blot or RT-PCR. (J:124044)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hrk Mutation:  0 strains or lines available
References
Original:  J:124044 Coultas L, et al., Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis. J Cell Sci. 2007 Jun 15;120(Pt 12):2044-52
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory