Angptl4^{Gt(OST352973)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Angptl4^{Gt(OST352973)Lex}
• Name: angiopoietin-like 4; gene trap OST352973, Lexicon Genetics
• MGI ID: MGI:3716687
• Synonyms: Angptl4^-
• Gene: Angptl4 Location: Chr17:33993874-34000549 bp, - strand Genetic Position: Chr17, 17.98 cM
• Alliance: Angptl4^{Gt(OST352973)Lex} page

Mutation origin

• Mutant Cell Line: OST352973
• Germline Transmission: Earliest citation of germline transmission: J:122968
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector was inserted into intron 2 of the locus. RT-PCR did not detect endogenous transcript in kidney and liver from mutants. (J:122968)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST352973	CG633380 ; (MGI Seq Detail)	3' RACE	Chr17:33996051-33999622 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  1 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Angptl4 Mutation: 31 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:122968 Desai U, et al., Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11766-71
• All: 13 reference(s)