Plin1^tm1Asg
Targeted Allele Detail

Summary

• Symbol: Plin1^tm1Asg
• Name: perilipin 1; targeted mutation 1, Andrew S Greenberg
• MGI ID: MGI:3710993
• Synonyms: PeriKO
• Gene: Plin1 Location: Chr7:79370912-79382652 bp, - strand Genetic Position: Chr7, 45.11 cM
• Alliance: Plin1^tm1Asg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113735
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 (nucleotides 3515-3887) was replaced with a neomycin resistance cassette, thereby disrupting the coding of all known mRNAs. (J:113735)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plin1 Mutation: 30 strains or lines available

References

• Original: J:113735 Miyoshi H, et al., Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. J Biol Chem. 2006 Jun 9;281(23):15837-44
• All: 3 reference(s)