Card10^tm1Xlin
Targeted Allele Detail

Summary

• Symbol: Card10^tm1Xlin
• Name: caspase recruitment domain family, member 10; targeted mutation 1, Xin Lin
• MGI ID: MGI:3710003
• Synonyms: Carma3^-
• Gene: Card10 Location: Chr15:78659338-78687242 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Card10^tm1Xlin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121114
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 3, which encodes a large part of the CARD domain. RT-PCR and Western blot confirmed gene disruption. (J:121114)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Card10 Mutation: 37 strains or lines available

References

• Original: J:121114 Grabiner BC, et al., CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation. Genes Dev. 2007 Apr 15;21(8):984-96
• All: 3 reference(s)