Mbp^jve
Chemically induced Allele Detail

Summary

• Symbol: Mbp^jve
• Name: myelin basic protein; jive
• MGI ID: MGI:3708458
• Synonyms: mbp^jive
• Gene: Mbp Location: Chr18:82493271-82603762 bp, + strand Genetic Position: Chr18, 55.84 cM, cytoband E2-E4
• Alliance: Mbp^jve page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This phenotypic mutant was identified in an ENU mutagenesis screen. A deletion of exons 3-6 was detected. Authors were unable to bridge the deleted junction, suggesting a translocation or inversion may be present. Western blot analysis of brain tissue confirmed the absence of protein expression in adult homozygous mutant mice. (J:221049)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mbp Mutation: 30 strains or lines available

References

• Original: J:119820 Schwander M, et al., A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci. 2007 Feb 28;27(9):2163-75
• All: 2 reference(s)