Gins1^tm1Ntak
Targeted Allele Detail

Summary

• Symbol: Gins1^tm1Ntak
• Name: GINS complex subunit 1; targeted mutation 1, Nobuyuki Takakura
• MGI ID: MGI:3706309
• Synonyms: Psf1^-
• Gene: Gins1 Location: Chr2:150751482-150773200 bp, + strand Genetic Position: Chr2, 74.75 cM, cytoband H1
• Alliance: Gins1^tm1Ntak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119867
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 was replaced by homologous recombination with a lacZ and a neomycin resistance cassette. Northern blot demonstrated reduced transcript levels in mutant testis. (J:119867)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gins1 Mutation: 19 strains or lines available

References

• Original: J:119867 Ueno M, et al., PSF1 is essential for early embryogenesis in mice. Mol Cell Biol. 2005 Dec;25(23):10528-32
• All: 2 reference(s)