Del(16Dgcr2-Hira)1Rak
Targeted Allele Detail

Summary

• Symbol: Del(16Dgcr2-Hira)1Rak
• Name: deletion, Chr 16, Raju Kucherlapati 1
• MGI ID: MGI:3702642
• Synonyms: Del1Rak, Lgdel
• Gene: Del(16Dgcr2-Hira)1Rak Location: Chr16:17658219-18789059 bp Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67796
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S6/SvEvTac and STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted
• Mutations: Intergenic deletion, Intragenic deletion
• Del(16Dgcr2-Hira)1Rak involves 51 genes/genome features (Gm26170, Gm26219, Gm15954 ...) View all
• Mutation details: Mutant mice containing loxP sites inserted into the Dgcr2^tm1Ais and Hira^tm2Pjs loci were crossed with mice expressing cre in the germline to remove the floxed region between the loci. This deletion encompasses 24 genes. (J:67796)

Disease models

Expression

In Mice Carrying this Mutation:	18 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(16Dgcr2-Hira)1Rak Mutation: 0 strains or lines available

References

• Original: J:67796 Merscher S, et al., TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell. 2001 Feb 23;104(4):619-29
• All: 23 reference(s)