Dp(16Dgcr2-Arvcf)1Ais
Targeted Allele Detail

Summary

• Symbol: Dp(16Dgcr2-Arvcf)1Ais
• Name: duplication, Chr 16, Arthur I Skoultchi 1
• MGI ID: MGI:3702631
• Gene: Dp(16Dgcr2-Arvcf)1Ais Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64380
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted
• Mutation: Duplication
• Dp(16Dgcr2-Arvcf)1Ais involves 28 genes/genome features (Gm20518, Dgcr2, Tssk1 ...) View all
• Mutation details: Targeting vectors containing loxP sites in the DiGeorge syndrome critical region gene 2 and armadillo repeat gene deleted in velo-cardio-facial syndrome were introduced into ES cells in trans. Subsequent transient cre expression in ES cells containing loxP sites on opposite chromosomes resulted in the reciprocal duplication of the Dcgr2-Arvcf interval. (J:64380)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dp(16Dgcr2-Arvcf)1Ais Mutation: 0 strains or lines available

References

• Original: J:64380 Puech A, et al., Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10090-5
• All: 2 reference(s)