Igh^tm1.1Lnit
Targeted Allele Detail

Summary

• Symbol: Igh^tm1.1Lnit
• Name: immunoglobulin heavy chain complex; targeted mutation 1.1, Lars Nitschke
• MGI ID: MGI:3702524
• Synonyms: DQ52^-
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119484
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Deletion
• Igh^tm1.1Lnit involves 1 genes/genome features (Igh) View all
• Mutation details: This allele contains a single loxP site in place of DQ52, following cre mediated deletion of a floxed neomycin resistance cassette and HSV-tk that had been inserted in place of DQ52 and all its flanking sequences. In addition, the targeting vector replaced a wild-type HindIII site between JH3 and JH4 with an EcoRV site. (J:119484)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 45 strains or lines available

References

• Original: J:119484 Nitschke L, et al., Deletion of the DQ52 element within the Ig heavy chain locus leads to a selective reduction in VDJ recombination and altered D gene usage. J Immunol. 2001 Feb 15;166(4):2540-52
• All: 2 reference(s)