Lap3^tm1Klr
Targeted Allele Detail

Summary

• Symbol: Lap3^tm1Klr
• Name: leucine aminopeptidase 3; targeted mutation 1, Kenneth L Rock
• MGI ID: MGI:3702002
• Synonyms: LAP^-
• Gene: Lap3 Location: Chr5:45650716-45670033 bp, + strand Genetic Position: Chr5, 24.98 cM
• Alliance: Lap3^tm1Klr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119392
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-13 (19.2kb) were replaced with a lacZ-neo cassette creating a null allele. The absence of protein product was confirmed by western blot of MEFs with or without IFN treatment. (J:119392)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lap3 Mutation: 36 strains or lines available

References

• Original: J:119392 Towne CF, et al., Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation. J Immunol. 2005 Nov 15;175(10):6605-14
• All: 2 reference(s)