Gapdh^M8Neu
Chemically and radiation induced Allele Detail

Summary

• Symbol: Gapdh^M8Neu
• Name: glyceraldehyde-3-phosphate dehydrogenase; mutation 8, Neuherberg
• MGI ID: MGI:3701520
• Synonyms: GAPDH5447
• Gene: Gapdh Location: Chr6:125138812-125143450 bp, - strand Genetic Position: Chr6, 59.32 cM, cytoband C
• Alliance: Gapdh^M8Neu page

Mutation origin

• Strain of Origin: (101 x C3H)F1 X T-stock

Mutation description

• Allele Type: Chemically and radiation induced
• Mutation: Intragenic deletion
• Mutation details: This mutation, induced by the combination of 3-aminobenzamide and 6 Gy irradiation, comprises a deletion of 20 nucleotides in exon 2 that generates a shift in the translational reading frame resulting in a presumed abbreviated protein of 73 amino acids. (J:126359)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gapdh Mutation: 40 strains or lines available

References

• Original: J:126359 Pretsch W, et al., Genetic, biochemical, and molecular characterization of nine glyceraldehyde-3-phosphate dehydrogenase mutants with reduced enzyme activity in Mus musculus. Mamm Genome. 2007 Oct;18(10):686-92
• All: 1 reference(s)