St3gal1^tm2Jxm
Targeted Allele Detail

Summary

• Symbol: St3gal1^tm2Jxm
• Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 1; targeted mutation 2, Jamey Marth
• MGI ID: MGI:3699717
• Synonyms: ST3Gal-1^F
• Gene: St3gal1 Location: Chr15:66974724-67048575 bp, - strand Genetic Position: Chr15, 29.3 cM
• Alliance: St3gal1^tm2Jxm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79167
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was used to place a floxed neomycin-thymidine kinase expression cassette upstream of exon two and an additional loxP site in intron 2. ES cells were transfected with Cre expression plasmid to excise the neo fragment, leaving the floxed gene. (J:79167)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any St3gal1 Mutation: 41 strains or lines available

References

• Original: J:79167 Priatel JJ, et al., The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis. Immunity. 2000 Mar;12(3):273-83
• All: 2 reference(s)