Ptcratm1(icre)Hjf
Targeted Allele Detail
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Symbol: |
Ptcratm1(icre)Hjf |
Name: |
pre T cell antigen receptor alpha; targeted mutation 1, Hans Jorg Fehling |
MGI ID: |
MGI:3696089 |
Synonyms: |
pTa/iCre, Ptcratm1(cre)Hjf |
Gene: |
Ptcra Location: Chr17:47066589-47074638 bp, - strand Genetic Position: Chr17, 22.9 cM, cytoband D-E1
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Alliance: |
Ptcratm1(icre)Hjf page
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Germline Transmission: |
Earliest citation of germline transmission:
J:117041
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Ptcratm1(icre)Hjf expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Ptcra (MGI:104857) |
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Mutation details: A mini-gene encoding a codon-optimized cre, the SV40 polyadenylation signal and an Frt-flanked neo selection cassette was inserted into the first exon of the Ptcra (pTalpha) gene in ES cells. The neo was excised in vitro by transient transfection with flippase. Expression of cre is observed in immature DP thymocytes and in more mature SP cells.
(J:117041, J:197923)
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Generation of the Ptcratm1(icre)Hjf allele |
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Ptcra
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:117041 Luche H, et al., Faithful activation of an extra-bright red fluorescent protein in 'knock-in' Cre-reporter mice ideally suited for lineage tracing studies. Eur J Immunol. 2007 Jan;37(1):43-53 |
All: |
9 reference(s) |
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