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Targeted Allele Detail
Symbol: Ptcratm1(icre)Hjf
Name: pre T cell antigen receptor alpha; targeted mutation 1, Hans Jorg Fehling
MGI ID: MGI:3696089
Synonyms: pTa/iCre, Ptcratm1(cre)Hjf
Gene: Ptcra  Location: Chr17:47066589-47074638 bp, - strand  Genetic Position: Chr17, 22.9 cM, cytoband D-E1
Alliance: Ptcratm1(icre)Hjf page
Germline Transmission:  Earliest citation of germline transmission: J:117041
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
Ptcratm1(icre)Hjf expression driven by 1 gene
Mutation detailsA mini-gene encoding a codon-optimized cre, the SV40 polyadenylation signal and an Frt-flanked neo selection cassette was inserted into the first exon of the Ptcra (pTalpha) gene in ES cells. The neo was excised in vitro by transient transfection with flippase. Expression of cre is observed in immature DP thymocytes and in more mature SP cells. (J:117041, J:197923)
Generation of the Ptcratm1(icre)Hjf allele
 Tissue activity of this recombinase allele
Driver: Ptcra (mouse)
Summary of all recombinase alleles driven by Ptcra.

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ptcra Mutation:  16 strains or lines available
Original:  J:117041 Luche H, et al., Faithful activation of an extra-bright red fluorescent protein in 'knock-in' Cre-reporter mice ideally suited for lineage tracing studies. Eur J Immunol. 2007 Jan;37(1):43-53
All:  11 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory