Trpa1^tm1Jul
Targeted Allele Detail

Summary

• Symbol: Trpa1^tm1Jul
• Name: transient receptor potential cation channel, subfamily A, member 1; targeted mutation 1, David Julius
• MGI ID: MGI:3692770
• Synonyms: Trpa1^-
• Gene: Trpa1 Location: Chr1:14942872-14989086 bp, - strand Genetic Position: Chr1, 4.5 cM
• Alliance: Trpa1^tm1Jul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115886
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Most of exon 23, encoding the putative pore and part of the sixth transmembrane domain, was deleted. A neomycin cassette was removed through self-excision in the male germline. RT-PCR confirmed absence of transcript in mutants. (J:115886)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpa1 Mutation: 92 strains or lines available

References

• Original: J:115886 Bautista DM, et al., TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006 Mar 24;124(6):1269-82
• All: 52 reference(s)