Nlrc4^tm1Nnz
Targeted Allele Detail

Summary

• Symbol: Nlrc4^tm1Nnz
• Name: NLR family, CARD domain containing 4; targeted mutation 1, Gabriel Nunez
• MGI ID: MGI:3664623
• Synonyms: Card12^-, Ipaf^-, IPAF^-, Nlrc4^-
• Gene: Nlrc4 Location: Chr17:74733254-74766140 bp, - strand Genetic Position: Chr17, 45.64 cM
• Alliance: Nlrc4^tm1Nnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112671
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 1 and 2 were replaced with an IRES-Betageo. (J:112671)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrc4 Mutation: 67 strains or lines available

References

• Original: J:112671 Franchi L, et al., Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol. 2006 Jun;7(6):576-82
• All: 32 reference(s)