About   Help   FAQ
Spontaneous Allele Detail
Symbol: Il3ram1
Name: interleukin 3 receptor, alpha chain; mutation 1
MGI ID: MGI:3652833
Synonyms: Il3raA/J, Il3ran
Gene: Il3ra  Location: Chr14:8114270-8123851 bp, - strand  Genetic Position: Chr14, 7.08 cM
Alliance: Il3ram1 page
Strain of Origin:  multiple strains
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
Mutation detailsSequence analysis revealed A/J mice lack the sequence corresponding to exon 8, which encodes 10 amino acid residues in the extracellular domain. Aberrant splicing was due to a 5 base pair deletion at the branch point in intron 7. (J:23971)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 12 strains available      Cell Lines: 0 lines available
Carrying any Il3ra Mutation:  36 strains or lines available
This allele has been identified in A/J, A/WySnJ, A/HeJ, C58/J, RF/J, AKR/J, SM/J, BUB/BnJ, CE/J, and NZB/B1NJ. see J:24918.
Original:  J:23971 Ichihara M, et al., Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor alpha subunit gene. EMBO J. 1995 Mar 1;14(5):939-50
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.23
The Jackson Laboratory