Malt1^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Malt1^tm1Mak
• Name: MALT1 paracaspase; targeted mutation 1, Tak Mak
• MGI ID: MGI:3639305
• Synonyms: Malt1^-, Malt1^tm1Jrld
• Gene: Malt1 Location: Chr18:65564010-65611959 bp, + strand Genetic Position: Chr18, 38.56 cM
• Alliance: Malt1^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109545
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 8 of the locus. Exon 8 encodes the N-terminal region of the paracaspase domain. RT-PCR confirmed loss of transcript in mutant thymocytes. Western blot failed to detect protein from mutant spleens. (J:109545)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Malt1 Mutation: 33 strains or lines available

References

• Original: J:109545 Ruland J, et al., Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity. 2003 Nov;19(5):749-58
• All: 26 reference(s)