Pcdhg^tm1Xzw
Targeted Allele Detail

Summary

• Symbol: Pcdhg^tm1Xzw
• Name: protocadherin gamma cluster; targeted mutation 1, Xiaozhong Wang
• MGI ID: MGI:3623601
• Synonyms: Pcdh-gamma^fusg, Pcdh-gamma^GFP, Pcdhgc3^tm1Jrs, Pcdhg^tm1Jrs
• Gene: Pcdhg Location: unknown Genetic Position: Chr18, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107735
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (No functional change, Reporter)
• Mutation: Insertion
• Mutation details: A GFP was fused to the C-terminal (third) shared exon via cre-mediated recombination. Expression of the fusion protein was concentrated in the postsynaptic density fraction. Immunostaining demonstrated expression in most, if not all, regions of the neonatal nervous system, with high levels in the spinal cord. (J:107735)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcdhg Mutation: 12 strains or lines available

References

• Original: J:107735 Wang X, et al., Gamma protocadherins are required for survival of spinal interneurons. Neuron. 2002 Dec 5;36(5):843-54
• All: 7 reference(s)