Cebpb^tm1Es
Targeted Allele Detail

Summary

• Symbol: Cebpb^tm1Es
• Name: CCAAT/enhancer binding protein beta; targeted mutation 1, Esta Sterneck
• MGI ID: MGI:3623142
• Synonyms: C/EBPbeta^f, C/EBPbeta^fl, Cebpb^tm1Rcsm
• Gene: Cebpb Location: Chr2:167530835-167532338 bp, + strand Genetic Position: Chr2, 87.58 cM
• Alliance: Cebpb^tm1Es page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107334
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank the coding sequence with loxP sites and insert a floxed neo cassette. Northern blot showed that mRNA levels were not affected in various tissues tested. (J:107334)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cebpb Mutation: 23 strains or lines available

References

• Original: J:107334 Sterneck E, et al., Conditional ablation of C/EBP beta demonstrates its keratinocyte-specific requirement for cell survival and mouse skin tumorigenesis. Oncogene. 2006 Feb 23;25(8):1272-6
• All: 21 reference(s)