Ly9^tm1Mckn
Targeted Allele Detail

Summary

• Symbol: Ly9^tm1Mckn
• Name: lymphocyte antigen 9; targeted mutation 1, David J McKean
• MGI ID: MGI:3618122
• Gene: Ly9 Location: Chr1:171416172-171434917 bp, - strand Genetic Position: Chr1, 79.54 cM
• Alliance: Ly9^tm1Mckn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105482
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3' part of exon 2 and all of intron 2 have been replaced by a neomycin resistance gene. Western blot analysis of thymocytes and FACS analysis of splenocytes from homozygous mutant mice using rabbit antisera against the extracellular domain detected no LY9 (CD229) protein on these cells. (J:105482)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ly9 Mutation: 45 strains or lines available

Notes

Despite a significant defect in early T cell activation and a slight but significant defect in the Th2 response of CD4⁺ T cells, homozygous mutant mice mount appropriate T and B cell responses to lymphocytic choriomeningitis virus, their NKT cell development is normal, and mutant macrophages exhibit no defects in cytokine production or bacterial killing.

References

• Original: J:105482 Graham DB, et al., Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice. J Immunol. 2006 Jan 1;176(1):291-300
• All: 5 reference(s)