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QTL Variant Detail
QTL variant: Rmp4C57BL/6NCr
Name: resistance to mousepox 4; C57BL/6NCr
MGI ID: MGI:3617640
QTL: Rmp4  Location: unknown  Genetic Position: Chr1, Syntenic
Strain of Specimen:  C57BL/6NCr
Allele Type:    QTL
Mutation:    Undefined
    This allele confers resistance to ectromelia virus compared to DBA/2NCr. (J:29241)
View phenotypes and curated references for all genotypes (concatenated display).

Mapping and Phenotype information for this QTL, its variants and associated markers


As a first step towards mapping Rmp4, authors identified the autosomal regions of D2.B6-Rmp4 mice that were of C57BL/6NCr origin (C57BL/6NCr is a mouse strain which is resistant to ectromelia virus). They selected a panel of 422 provisionally mapped informative Mit microsatellite markers dispersed throughout the 19 autosomes, and found that all of the microsatellites in the D2.B6-Rmp4 mice were of DBA/2NCr origin except for five consecutive Mit microsatellites (D1Mit140, D1Mit33, D1Mit106, D1Mit57 and D1Mit110) spanning a distance of 9.1 cM on distal mouse Chromosome 1 which were of C57BL/6NCr origin. In this manner the authors were able to map the gene responsible for ectromelia virus resistance in C57BL/6NCr to the distal part of mouse Chromosome 1. Potential candidate genes for Rmp4 include Cfh (74.1 cM), Sell (86.6 cM), Fcgr2b (92.3 cM), Ly9 (93.3 cM), Cd48 (93.3 cM), Apcs (94.2 cM), and Ifi203 (95.31 cM).

Original:  J:29241 Brownstein DG, et al., Chromosome mapping of Rmp-4, a gonad-dependent gene encoding host resistance to mousepox. J Virol. 1995 Nov;69(11):6958-64
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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