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QTL Variant Detail
QTL variant: ScomBALB/cBy
Name: scopolamine modification of exploratory activity; BALB/cBy
MGI ID: MGI:3615633
QTL: Scom  Location: unknown  Genetic Position: Chr17, Syntenic
Strain of Specimen:  BALB/cBy
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


Inbred strain C57BL/6By exhibits higher short term exploratory activity compared to inbred strain BALB/cBy. However, this phenotype is reversed when animals are administered scopolomine in that BALB/cBy now exhibits higher short term exploratory activitycompared to C57BL/6By. Analysis of 7 CXB (C=BALB/cBy; B=C57BL/6By) recombinant inbred (RI) strains mapped A QTL named Scom (scopolamine modification of exploratory activity) near the H2 locus at 23 cM on mouse Chromosome 17.

A previously identified QTL named Exa (exploratory activity) mapped to mouse Chromosome 4 in congenic line H(w26) derived from BALB/cBy donor and C57BL/6By recipient strains. The congenic exhibits low exploratory activity similar to the BALB/cBy donor strain, indicating that Exa exhibits decreased exploratory activity when derived from BALB/cBy.

Original:  J:5355 Oliverio A, et al., Exploratory activity: genetic analysis of its modification by scopolamine and amphetamine. Physiol Behav. 1973 May;10(5):893-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory