About   Help   FAQ
Trpm5tm1Sdmk
Targeted Allele Detail
Summary
Symbol: Trpm5tm1Sdmk
Name: transient receptor potential cation channel, subfamily M, member 5; targeted mutation 1, Sami Damak
MGI ID: MGI:3612408
Synonyms: Trpm5-, Trpm5 KO
Gene: Trpm5  Location: Chr7:142625266-142648379 bp, - strand  Genetic Position: Chr7, 88.11 cM
Alliance: Trpm5tm1Sdmk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104626
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsSequence encompassing 2.4 kb of the 5' flanking region comprising the promoter and exons 1-4, including the translation start site in exon 2, was deleted. Immunohistochemistry failed to detect protein in taste buds of mutant mice. (J:103852, J:122002)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpm5 Mutation:  56 strains or lines available
References
Original:  J:104626 Rong M, et al., Signal Transduction of Umami Taste: Insights from Knockout Mice. Chem Senses. 2005 Jan;30(suppl_1):i33-i34
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/16/2024
MGI 6.23
The Jackson Laboratory