Bmp7^tm3(Bmp7)Rob
Targeted Allele Detail

Summary

• Symbol: Bmp7^tm3(Bmp7)Rob
• Name: bone morphogenetic protein 7; targeted mutation 3, Elizabeth J Robertson
• MGI ID: MGI:3611800
• Synonyms: BMP7^7myc7
• Gene: Bmp7 Location: Chr2:172709805-172782114 bp, - strand Genetic Position: Chr2, 95.54 cM
• Alliance: Bmp7^tm3(Bmp7)Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103587
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The Bmp7 cDNA with a myc tag was inserted in place of 263 bases including the endogenous translational start site, but preserving the endogenous transcriptional regulatory elements. Mutant kidneys abundantly express the knock-in transcript but lack wild type transcript. (J:103587)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp7 Mutation: 37 strains or lines available

References

• Original: J:103587 Oxburgh L, et al., BMP4 substitutes for loss of BMP7 during kidney development. Dev Biol. 2005 Oct 15;286(2):637-46
• All: 1 reference(s)