Vegfb^tm1Ueks
Targeted Allele Detail

Summary

• Symbol: Vegfb^tm1Ueks
• Name: vascular endothelial growth factor B; targeted mutation 1, Ulf Eriksson
• MGI ID: MGI:3609979
• Synonyms: VEGF-B^-
• Gene: Vegfb Location: Chr19:6959841-6965019 bp, - strand Genetic Position: Chr19, 5.12 cM, cytoband B
• Alliance: Vegfb^tm1Ueks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103156
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette was inserted via homologous recombimation to replace part of exons 3 and 4. The deleted sequence was about 330 bp in length and encoded the VEGF homology domain, including 7 of the 8 invariant cystein residues involved in intermolecular and intramolecular disulfide bonding and the VEGFR-1 binding epitope. Western blot failed to detect protein in mutant heart and muscle. (J:103156)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vegfb Mutation: 23 strains or lines available

References

• Original: J:103156 Aase K, et al., Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect. Circulation. 2001 Jul 17;104(3):358-64
• All: 12 reference(s)